apalutamide will lessen the extent or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medication which have been CYP3A4 substrates may lead to reduced publicity to those medications.Akutt og alvorlig allergisk reaksjon